연구개발 고콜레스테롤
치료제
지방간
| 작용기전 | 효능 (% change) | 부작용 |
|---|---|---|
| HMG CoA reductase inhibitors | ↓ LDL (18-55), ↑ HDL (5-15), ↓ TG (7-30) | Myopathy, ↑ Liver enzymes |
| Cholesterol absorption inhibitors | ↓ LDL (14-18), ↑ HDL (1-3), ↓ TG (2) | Headache, GI distress |
| Nicotinic Acid | ↓ LDL (15-30), ↑ HDL (15-35), ↓ TG (20-50) |
Flushing, Hyperglycemia Hyperuricemia, GI distress, Hepatotoxicity |
| Fibric Acids | ↓ LDL (5-20), ↑ HDL (10-20), ↓ TG (20-50) | Dyspepsia, Gallstones, Myopathy |
| Bile Acid sequestrants | ↓ LDL, ↑ HDL, No change in TG |
GI distress, Constipation ↓ absorption of other drugs |
Statin의 한계
Most Common Reasons for
STOPPING
STATIN USE
Reasons for stopping statin use among former statin users
- 고콜레스테롤증 시장의 90%를 차지하는 스타틴 수용한 부작용으로 한계를 지니고 있음
- 햄프랜드는 이 한계를 극복할 심마립 대마추출물에서 찾았음
Statin side effect
Common
- headache
- dizziness
- feeling sick
- feeling unusually tired or physically weak
- digestive system problems, such as constipation, diarrhea, indigestion or farting
- muscle pain
- sleep problems
- low blood platelet count
Uncommon
- being sick
- memory problems
- hair loss
- pins and needles
- inflammation of the liver (hepatitis), which can cause flu-like symptoms
- inflammation of the pancreas (pancreatitis), which can cause stomach pain
- skin problems, such as acne or an itchy red rash
- sexual problems, such as loss of libido (reduced sex drive) or erectile dysfunction
Rare
- muscle weakness (myopathy)
- loss of sensation or tingling in the nerve endings of the hands and feet (peripheral neuropathy)
- tendon problems (tendons are tough cords of tissue that connect muscles to bones)